High level contamination by natural and industrial
sources of the alkali earth metal, barium (Ba) has been
identified in the ecosystems/workplaces that are associated
with high incidence clustering of multiple sclerosis (MS)
and other neurodegenerative diseases such as the
transmissible spongiform encephalopathies (TSEs) and
amyotrophic lateral sclerosis (ALS).
Analyses of ecosystems supporting the most renowned MS
clusters in Saskatchewan, Sardinia, Massachusetts, Colorado,
Guam, NE Scotland demonstrated consistently elevated levels
of Ba in soils (mean: 1428 ppm) and vegetation (mean: 74
ppm) in relation to mean levels of 345 and 19 ppm recorded
in MS-free regions adjoining. The high levels of Ba stemmed
from local quarrying for Ba ores and/or use of Ba in
paper/foundry/welding/textile/oil and gas well related
industries, as well as from the use of Ba as an atmospheric
aerosol spray for enhancing/refracting the signalling of
radio/radar waves along military jet flight paths, missile
test ranges, etc.
It is proposed that chronic contamination of the
biosystem with the reactive types of Ba salts can initiate
the pathogenesis of MS; due to the conjugation of Ba with
free sulphate, which subsequently deprives the endogenous
sulphated proteoglycan molecules (heparan sulfates) of their
sulphate co partner, thereby disrupting synthesis of
S-proteoglycans and their crucial role in the fibroblast
growth factor (FGF) signalling which induces oligodendrocyte
progenitors to maintain the growth and structural integrity
of the
myelin sheath.
Loss of S-proteoglycan activity explains other key
facets of MS pathogenesis; such as the aggregation of
platelets and the proliferation of superoxide generated
oxidative stress. Ba intoxications disturb the
sodium-potassium ion pump–another key feature of the MS
profile. The co-clustering of various neurodegenerative
diseases in these Ba-contaminated ecosystems suggests that
the pathogenesis of all of these diseases could pivot upon a
common disruption of the sulphated proteoglycan-growth
factor mediated signalling systems.
Individual genetics dictates which specific disease
emerges at the end of the day.
Purdey M.
SOURCE: Oregon Skywatch © 2008 Oregon Skywatch
(16/06/08)
|
