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Peripheral Nervous System

SOURCE: training.seer.cancer.gov/

 

 

 

 

The peripheral nervous system (PNS) refers those nerves (neurons) that are not part of the brain or spinal cord. These nerves form the communication network between the CNS and the body parts.  Nerves inside the brain and spinal cord are part of the central nervous system (CNS). PNS nerves have their cell bodies (ganglia) inside the CNS but their length outside it. The PNS consists of neurons with both myelinated and un-myelinated axons. All the cranial nerves (the 12 pairs of nerves leaving the base of the braincase) are part of the peripheral nervous system although the second cranial nerve (the optic nerve) can be considered as part of the brain.

 

The peripheral nervous system is further subdivided into the somatic nervous system and the autonomic nervous system. The somatic nervous system consists of nerves that go to the skin and muscles and is involved in conscious activities. The autonomic nervous system consists of nerves that connect the CNS to the visceral organs such as the heart, stomach, and intestines. It mediates unconscious activities.

 

There are two kinds of nerve in the Peripheral Nervous System:

  1. Motor or efferent nerves. These are the nerves that connect to muscles in the limbs, torso, face and internal organs. They carry nerve signals from the CNS and make body parts move. The cell bodies of the motor nerves connect to CNS in the shaft of grey matter in the spine called the anterior horn. They terminate at a neuromuscular junction known as the motor plate or motor end plate. Neurotransmitters released by the motor nerves into the motor plate cause the muscle to contract.
     

  2. Sensory or afferent nerves. These are nerves that connect to sensory organs and sensors in the skin, muscle and internal organs. They take relay nerve signals to the CNS. They convey heat, touch, position (proprioceptive), balance, sound and other information from the limbs and sense and internal organs. Sensory nerves terminate in the CNS at the root ganglion.

The peripheral nervous system is divided into two parts:

  1. The sensory-somatic nervous system (SNS).
     

      The SNS is performs all our interactions with the physical world such as control of our limbs and receiving of conscious information from our senses. It consists of the 12 pairs of cranial nerves and the 31 pairs of spinal nerves.
       

  2. The autonomic nervous system (ANS).
     

      The ANS consists of both motor and sensory nerves which run both to and from the central nervous system and fulfills "automatic" functions that we are seldom aware of such as heart activity and the release of hormones. The autonomic nervous system is further divided into the sympathetic nervous system and the parasympathetic nervous system.

Structure of a Nerve

 

A nerve contains bundles of nerve fibers, either axons or dendrites, surrounded by connective tissue. Sensory nerves contain only afferent fibers, long dendrites of sensory neurons. Motor nerves have only efferent fibers, long axons of motor neurons. Mixed nerves contain both types of fibers. A connective tissue sheath called the epineurium surrounds each nerve.    Each bundle of nerve

fibers is called a fasciculus and is surrounded by a layer of connective tissue called the perineurium. Within the fasciculus, each individual nerve fiber, with its myelin and neurilemma, is surrounded by connective tissue called the endoneurium. A nerve may also have blood vessels enclosed in its connective tissue wrappings.

 

 

Cranial Nerves

 

Twelve pairs of cranial nerves emerge from the inferior surface of the brain. All of these nerves, except the vagus nerve , pass through foramina of the skull to innervate structures in the head, neck, and facial region.

 

The cranial nerves are designated both by name and by Roman numerals, according to the order in which they appear on the inferior surface of the brain. Most of the nerves have both sensory and motor components. Three of the nerves are associated with the special senses of smell, vision, hearing, and equilibrium and have only sensory fibers. Five other nerves are primarily motor in function but do have some sensory fibers for proprioception. The remaining four nerves consist of significant amounts of both sensory and motor fibers.  Acoustic neuromas are benign fibrous growths that arise from the balance nerve, also called the eighth cranial nerve or Vestibulocochlear nerve. These tumors are non-malignant, meaning that they do not spread or metastasize to other parts of the body. The location of these tumors is deep inside the skull, adjacent to 

vital brain centers in the brain stem. As the tumors enlarge, they involve surrounding structures which have to do with vital functions. In the majority of cases, these tumors grow slowly over a period of years. In other cases, the growth rate is more rapid and patients develop symptoms at a faster pace. Usually, the symptoms are mild and many patients are not diagnosed until some time after their tumor has developed. Many patients also exhibit no tumor growth over a number of years when followed by yearly MRI scans.

 

 

Spinal Nerves

 

Thirty-one pairs of spinal nerves emerge laterally from the spinal cord. Each pair of nerves corresponds to a segment of the cord and they are named accordingly. This means there are 8 cervical nerves, 12 thoracic nerves, 5 lumbar nerves, 5 sacral nerves, and 1 coccygeal nerve.

Each spinal nerve is connected to the spinal cord by a dorsal root and a ventral root. The cell bodies of the sensory neurons are in the dorsal root ganglion, but the motor neuron cell bodies are in the gray matter. The two roots join to form the spinal nerve just before the nerve leaves the vertebral column. Because all spinal nerves have both sensory and motor components, they are all mixed nerves.

 

 

Autonomic Nervous System

 

The autonomic nervous system is a visceral efferent system, which means it sends motor impulses to the visceral organs. It functions automatically and continuously, without conscious effort, to innervate smooth muscle, cardiac muscle, and glands. It is concerned with heart rate, breathing rate, blood pressure, body temperature, and other visceral activities that work together to maintain homeostasis.

The autonomic nervous system has two parts, the sympathetic division and the parasympathetic division. Many visceral organs are supplied with fibers from both divisions. In this case, one stimulates and the other inhibits. This antagonistic functional relationship serves as a balance to help maintain homeostasis.

 

Peripheral Nervous System links: